Santurce is located along the north-eastern coast of Puerto Rico. It lies south of the Atlantic Ocean, east of Old San Juan and west of Isla Verde. The district occupies an area of 5.24 square miles (13.6 km2) of land and 3.46 (8.96 km2) of water. It is surrounded by six bodies of water: San Juan Bay, Condado Natural Lagoon, the Martín Peña Channel, San José Lagoon, Los Corozos Lagoon, and the Atlantic Ocean with its respective beaches and estuaries.

Structures of architectural value and historical importance are located mainly throughout Avenida Ponce de León, Ashford Avenue and Avenida Fernández Juncos.

Public transportation is provided by several bus lines (locally known as guaguas) operated by the Puerto Rico Metropolitan Bus Authority and circulate along the main avenues of Ponce de León and Fernández Juncos among others.

In the peripheries of Santurce there is a rapid transit system called Tren Urbano. The Sagrado Corazón terminal station is located in the southeast section of the district in the neighborhood of Martín Peña.

Santurce is a few minutes away by car from the country’s main airport, Luis Munoz Marin International Airport, and from San Juan’s secondary commercial airport, Isla Grande Airport.